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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus.
 
Authors:  Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
 
Drug:  Gemfibrozil
 
Fish species:  Carp, crucian (goldfish)
 
Date:  2005
 
Sample:  blood, plasma
 
Ave Weight (gm):  26
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  1500 ug/l 14 d
 
Route:  BATH
 
Comments:  Conc in plasma approx 200 ug/L after 14 d exposure. Plasma testosertone reduced by 50%. Steroid acute regulatory protein transcript in testis reduced by 50% after 96 h exposure, but not after 14 d exposure. (Seasonal differences may account for this - Feb vs Nov). BCF=113.
 
Citation:  Aquatic Toxicology 73:44-54
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15892991&query_hl=10  Opens a new window
 
Genus Species:  Carassius auratus auratus
 
Drug Class:  Lipid Regulator
 
Wt gm-detail:  26.4+/-0.7g
 
Water temp (°C)-detail:  18+/-1°C
 
Dosage-detail:  1500 ug/l 14 d
 
Method:  LC/MS, MS
 
Authors-red:  Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
 
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