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U.S. Department of Health and Human Services

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Title:  Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
 
Authors:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
Drug:  Domoic acid
 
Fish species:  Salmon, coho
 
Date:  2007
 
Sample:  kidney
 
Ave Weight (gm):  48
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  10 mg/Kg sd
 
Route:  PO
 
Comments:  Domoic acid Cmax in kidney was around 9000ng/ml. This level was highest of all the other tissues suggesting that the primary route of toxin excretion may be via this organ. Residues almost nd after 312h; results estimated from graph. No neurotoxic activity in PO treated fish.
 
Citation:  Aquatic Toxicology 81:266-274
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2006.12.009  Opens a new window
 
Genus Species:  Oncorhynchus kisutch
 
Drug Class:  Organic-Phycotoxin
 
Wt gm-detail:  48 +/- 7g
 
Water temp (°C)-detail:  11-13 C
 
Dosage-detail:  A dose of 10 mg/kg administered in 250 ul volume once
 
Method:  ELISA
 
Authors-red:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
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