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U.S. Department of Health and Human Services

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Title:  Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
 
Authors:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
Drug:  Domoic acid
 
Fish species:  Salmon, coho
 
Date:  2007
 
Sample:  whole body*
 
Ave Weight (gm):  31
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  0.25, 0.9, 2.3, 3.5, 8.4, 16 and 34 mg/kg*
 
Route:  PO
 
Comments:  * Fish exposed to several doses for behavioral observation and dose-response curve. EC50 (toxin dose causing behavioral toxicity in 50% of population) was 2.9mg/kg fish. IC (intracoelomic) injection of domoic acid in juvenile coho resulted in excitotoxic symptoms including spiral-, circle-, and upside-down swimming. Euth with MS222.
 
Citation:  Aquatic Toxicology 81:266-274
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2006.12.009  Opens a new window
 
Genus Species:  Oncorhynchus kisutch
 
Drug Class:  Organic-Phycotoxin
 
Wt gm-detail:  31 +/- 3g
 
Water temp (°C)-detail:  11
 
Dosage-detail:  0.25+/-0.02, 0.9+/-0.04, 2.3+/-0.2, 3.5+/-0.2, 8.4+/-0.7, 16+/-0.3 and 34+/-0.5 mg/kg
 
Method:  Behavioral observations
 
Authors-red:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
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