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U.S. Department of Health and Human Services

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Title:  Kinetics and effects of dichloroacetic acid in rainbow trout
 
Authors:  Fitzsimmons PN, Hoffman AD, Lien GJ, Hammermeister DE, Nichols JW
 
Drug:  Dichloroacetic acid
 
Fish species:  Trout, rainbow
 
Date:  2009
 
t1/2-hr:  5
 
Sample:  blood, plasma
 
Ave Weight (gm):  900
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  0.05 mg/kg
 
Route:  IV
 
Comments:  Injection experiment. Four fish previously exposed to nominally 200 mg/L DCA for one week followed by one week depuration, "low dose - pre-treatment". AUC = 0.62.
 
Cl:  68
 
Vd:  486 mL/kg
 
Citation:  Aquatic Toxicology 94: 186-194
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2009.07.001  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Halogenated acetic acids
 
t1/2-detail:  5.3
 
Wt gm-detail:  800-1100
 
Water temp (°C)-detail:  11+/-1
 
Dosage-detail:  50 ug/kg
 
Method:  HPLC-UV, GC/ECD
 
Authors-red:  Fitzsimmons PN, Hoffman AD, Lien GJ, Hammermeister DE, Nichols JW
 
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