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U.S. Department of Health and Human Services

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Title:  Chronic effects assessment and plasma concentrations of the Beta-blocker propranolol in fathead minnows (Pimephales promelas)
 
Authors:  Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP
 
Drug:  Propanolol
 
Fish species:  Minnow, fathead
 
Date:  2009
 
Sample:  blood, plasma
 
Ave Weight (gm):  3
 
Ave Water temp (°C):  25
 
Water:  Freshwater
 
Dosage:  0.1 mg/L 21 d
 
Route:  BATH
 
Comments:  Fish were euthaized with MS-222 (0.5 mg/L). Cumulative egg production: 2540. Gonadal somatic index (%): Male-0.9, Female-10. Condition index: Male-1.5, Female 1.2. A high proportion of eggs (75-95%) from exposed fish pairs hatched. Egg hatch delayed by 1 day. Mean plasma concentration (mg/L): Male-0.0.34, Female-0.21.
 
Citation:  Aquatic Toxicology 95: 195-202
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2009.09.002  Opens a new window
 
Genus Species:  Pimephales promelas
 
Drug Class:  Beta adrenoreceptor blocker: non-specific
 
Wt gm-detail:  Males ranged 2.433-5.680g, females ranged 0.811-2.490g
 
Water temp (°C)-detail:  25+/-1
 
Dosage-detail:  Mean = 0.078 mg/L
 
Method:  LC/SPE
 
Authors-red:  Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP
 
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