Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  Differential uptake and oxidative stress response in zebrafish fed a single dose of the principal copper and zinc enriched sub-cellular fractions of Gammarus pulex.
 
Authors:  Khan FR, Bury NR, Hogstrand C
 
Drug:  Copper
 
Fish species:  Danio, zebra (zebrafish)
 
Date:  2010
 
Sample:  whole body-minus intestinal tract
 
Ave Weight (gm):  0.55
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  0.008 mg/kg sd
 
Route:  PO
 
Comments:  Water supplemented with 60 mg/L sea salt and 200 uM CaCl2. Dose was fed via accumulation in amphipods. Amphipods were dosed for 16d at 11 ug Cu/L added as 65CuCl2. Amphipod accumulated 7.4 ug 65Cu/g after 16d. Water supplemented with 60 mg/L sea salt and 200 uM CaCl2. Fed copper in MRG+exo from amphipod measured 8 ug Cu/g . Assimilation efficiency 8h post-dose=51.0%, 24h post-dose=4.7%, 72h post-dose=0.80%.
 
Citation:  Aquatic Toxicology 99:466-472
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2010.06.007  Opens a new window
 
Genus Species:  Danio rerio
 
Drug Class:  Metal-Copper
 
Wt gm-detail:  0.4-0.7g
 
Water temp (°C)-detail:  28 (as described in referenced paper)
 
Dosage-detail:  7.99+/-1.45 ug/g sd
 
Method:  ICP
 
Authors-red:  Khan FR, Bury NR, Hogstrand C
 
-
-