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U.S. Department of Health and Human Services

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Title:  Differential uptake and oxidative stress response in zebrafish fed a single dose of the principal copper and zinc enriched sub-cellular fractions of Gammarus pulex.
 
Authors:  Khan FR, Bury NR, Hogstrand C
 
Drug:  Zinc
 
Fish species:  Danio, zebra (zebrafish)
 
Date:  2010
 
Sample:  intestinal tract
 
Ave Weight (gm):  0.55
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  0.775 mg/kg sd
 
Route:  PO
 
Comments:  Water supplemented with 60 mg/L sea salt and 200 uM CaCl2. Dose was fed via accumulation in amphipods. Fed zinc in MLTP from aphipod measured at 775 ng Zn/g. Bi-phasic depuration of zinc with rapid loss of ingested radioactivity for the first 12h and little further loss between 24h and 72h. Assimilation efficiency 24h post-dose=39.0% significantly different from from MRG+exo fed fish. Zn concentration intestinal tract=4.40 ng Zn/g. MTLP intestinal lipid peroxidation in the form of melondialdehyde (MDA)=1.17 nmol MDA/mg protein was not significantly different from the MRG+exo fed fish or control fish.
 
Citation:  Aquatic Toxicology 99:466-472
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2010.06.007  Opens a new window
 
Genus Species:  Danio rerio
 
Drug Class:  Metal-Zinc
 
Wt gm-detail:  0.4-0.7g
 
Water temp (°C)-detail:  28 (as described in referenced paper)
 
Dosage-detail:  774.5+/-43.4 ng/g sd
 
Method:  Rad
 
Authors-red:  Khan FR, Bury NR, Hogstrand C
 
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