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Title:
Biotransformation and tissue distribution of 1,2,3,7-tetrachlorodibenzo-p-dioxin, 1,2,3,4,7-pentachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout.
Authors:
Sijm DTHM, Yarechewski AL, Muir DCG, Webster GRB, Seinen W, Opperhuizen A
Drug:
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Fish species:
Trout, rainbow
Date:
1990
t1/2-hr:
240
est:
est
Sample:
whole body-minus intestine
Ave Weight (gm):
125
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
3.5-8.0 ug/kg* sd
Route:
PO
Comments:
*Comparative study with and without Piperonylbutoxide (PBO)- (monooxygenase inhibitor). Total K2=0.191/d (without PBO). T 1/2 estimated from graph=10d.
Citation:
Chemosphere 21:845-866
Link:
http://dx.doi.org/10.1016/0045-6535(90)90166-Q
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Chlorinated-Pesticide
t1/2-detail:
10 d est from graph
Wt gm-detail:
75-175 g
Water temp (°C)-detail:
10 C
Dosage-detail:
3.5-8.0 ug/kg* sd
Method:
GC/EC, Rad
Authors-red:
Sijm DTHM, Yarechewski AL, Muir DCG, Webster GRB, Seinen W, Opperhuizen A
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