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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Biotransformation and tissue distribution of 1,2,3,7-tetrachlorodibenzo-p-dioxin, 1,2,3,4,7-pentachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout.
 
Authors:  Sijm DTHM, Yarechewski AL, Muir DCG, Webster GRB, Seinen W, Opperhuizen A
 
Drug:  TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin) + PBO (Piperonylbutoxide)
 
Fish species:  Trout, rainbow
 
Date:  1990
 
t1/2-hr:  480
 
est:  est
 
Sample:  whole body-minus intestine
 
Ave Weight (gm):  125
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  3.5-8.0 ug/kg* sd
 
Route:  PO
 
Comments:  *Comparative study with and without Piperonylbutoxide (PBO)- (monooxygenase inhibitor). Total K2=0.095/d (with PBO). T 1/2 estimated from graph=20d.
 
Citation:  Chemosphere 21:845-866
 
Link:  http://dx.doi.org/10.1016/0045-6535(90)90166-Q  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Chlorinated-Pesticide
 
t1/2-detail:  20 d est from graph
 
Wt gm-detail:  75-175 g
 
Water temp (°C)-detail:  10 C
 
Dosage-detail:  3.5-8.0 ug/kg* sd
 
Method:  GC/EC, Rad
 
Authors-red:  Sijm DTHM, Yarechewski AL, Muir DCG, Webster GRB, Seinen W, Opperhuizen A
 
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