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Title:
Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
Authors:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
Drug:
Morphine
Fish species:
Flounder, winter
Date:
2006
t1/2-hr:
34
Sample:
blood, plasma
Ave Weight (gm):
565
Ave Water temp (°C):
10
Water:
Saltwater
Dosage:
39 mg/kg sd
Route:
IP
Comments:
A = 63.5 +/- 8.0 mg/L, ± = 0.434 +/- 0.083 per hour, B = 8.76 +/- 2.19 mg/L, ² = 0.0274 +/- 0.0054 per hour, T1/2dist = 2.20 +/- 0.46 h, AUCexpo = 513 +/- 72 mg h/L, AUCarea = 583 +/- 74 mg h/L, AUMCexpo = 18,600 +/- 5970 mg h2/L, AUMCarea = 18,600 +/- 5990 h2/L, MRTarea = 27.9 +/- 6.6 h (Morphine Sulfate).
Cl:
0.076 L/kg/h
Citation:
Comparative Biochemistry and Physiology 143C:275-283
Link:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Pseudopleuronectes americanus
Drug Class:
Analgesic-Morphine
t1/2-detail:
34.1 +/- 7.3 h
Wt gm-detail:
565 +/- 76 g
Water temp (°C)-detail:
4 C initally acclimated to 10 C
Dosage-detail:
39.0 +/- 0.3 mg/kg
Method:
ELISA
Authors-red:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
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