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Title:
Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.
Authors:
Pritchard JB, Bend JR
Drug:
BAP-(Benzo-a-pyrene)
Fish species:
Flounder, southern
Date:
1991
Sample:
urine
Ave Weight (gm):
1750
Ave Water temp (°C):
13
Water:
Saltwater
Dosage:
2.5 umol/kg
Route:
IV/IM
Comments:
Half the dose administerd IV, the remainder was given IM. BaP (3H). Given with polyethyleneglycol (14C) as marker for GFR. Urine levels reduced in low temperature fish (4.7 uM vs 17.1 in controls at 23C).
Metabolites:
BaP7,8 diol
Citation:
Environmental Health Perspectives 90:85-92
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2050085
Genus Species:
Paralichthys lethostigma
Drug Class:
Organic-Hydrocarbon
Wt gm-detail:
500-3000 g
Water temp (°C)-detail:
12-14 C
Dosage-detail:
2.5 umol/kg
Method:
HPLC
Authors-red:
Pritchard JB, Bend JR
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