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U.S. Department of Health and Human Services

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Title:  Uptake, metabolism, and elimination of niclosamide by fish.
 
Authors:  Dawson VK, Schreier TM, Boogaard MA, Gingerich WH
 
Drug:  Niclosamide-(2,5-Dichloro-4-nitrosalicylanilide)
 
Fish species:  Catfish, channel
 
Date:  1999
 
t1/2-hr:  36
 
est:  est
 
Sample:  muscle+skin
 
Ave Weight (gm):  300
 
Ave Water temp (°C):  0
 
Water:  Freshwater
 
Dosage:  0.02 mg/L niclosamide + 2.0 mg/L TFM sd of 12h duration
 
Route:  BATH
 
Comments:  Fish exposed to a combination of 0.02mg/mL niclosamide and 2mg/L TFM-(3-trifluoromethyl-4-nitrophenol. Unpublished data by Dawson et al. Cage study performed in a stream. Cmax at 18h=0.05mg/kg.
 
Citation:  In: D.J. Smith, W.H. Gingerich and M.G. Beconi-Barker (Eds.). Xenobiotics in Fish. Kluwer Academic/Plenum Publishers. pp. 167-176.
 
Link:  none  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Antiparasitic-Niclosamide
 
t1/2-detail:  36hr
 
Wt gm-detail:  200-400 g
 
Water temp (°C)-detail:  Not Specified
 
Dosage-detail:  0.02 mg/L niclosamide + 2.0 mg/L TFM sd of 12h duration
 
Method:  HPLC
 
Authors-red:  Dawson VK, Schreier TM, Boogaard MA, Gingerich WH
 
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