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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics, Bioavailability, and Protein Binding of Oxolinic Acid in Rainbow Trout
 
Authors:  Ueno R, Tatsuno T
 
Drug:  Oxolinic Acid
 
Fish species:  Trout, rainbow
 
Date:  2003
 
t1/2-hr:  69
 
Sample:  blood, serum
 
Ave Weight (gm):  126
 
Ave Water temp (°C):  15
 
Water:  Freshwater
 
Dosage:  20 mg/kg
 
Route:  IV
 
Comments:  Cmax=22.4ug/ml - decresed to 0.30 at day 22. Half life alpha=0.78. AUC=968. Total body clearance=11.0h. Bioavailibility=43.4%. Protein binding ranged from 21.2 at 0.5h to 47.1 at 288h. It reached its low of 21% at 3 hours and a high of 69.1% at
 
Protein binding:  21-69%
 
Cl:  413.2
 
Vc:  0.69
 
Vd:  1.88
 
Citation:  ITE Letters on Batteries, New Technology & Medicine, Vol. 4, no. 4
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  69.3h
 
Wt gm-detail:  126g
 
Water temp (°C)-detail:  15
 
Dosage-detail:  20mg/kg BW
 
Method:  HPLC
 
Authors-red:  Ueno R, Tatsuno T
 
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