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Title:
Effect of temperature on pharmacokinetics of enrofloxacin in mud crab, Scylla serrata (forsskal), following oral administration.
Authors:
Fang WH, Hu LL, Yang XL, Hu K, Liang SC, Zhou S
Drug:
Enrofloxacin
Fish species:
Crab, mud
Date:
2008
t1/2-hr:
57
Sample:
blood, hemolymph
Ave Weight (gm):
135
Ave Water temp (°C):
26
Water:
Brackish
Dosage:
10 mg/kg sd
Route:
PO
Comments:
t1/2 alpha=1.5, Cmax=11.03 ug/ml, tmax 2 h, t1/2ka=1. 1, AUC 583.4 mg/L/h. Residues 0.5h=8.6, 1h=9.96, 2h=11, 4h=9.8, 6h=7.8, 12h=5.9, 24h=5.0, 48 h=4.5, 96h=1.9, 144h=1, 192h=0.5. MRT=63.7 h.
Cl:
0.018
Vd:
1.111
Citation:
J Fish Diseases 31:171-176
Link:
http://fdamedlibmd.library.ingentaconnect.com/content/bsc/jfd/2008/00000031/00000003/art00002
Genus Species:
Scylla serrata
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
56.5 h
Wt gm-detail:
120-150 g
Water temp (°C)-detail:
26+/-0.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Fang WH, Hu LL, Yang XL, Hu K, Liang SC, Zhou S
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