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U.S. Department of Health and Human Services

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Title:  Effect of temperature on pharmacokinetics of enrofloxacin in mud crab, Scylla serrata (forsskal), following oral administration.
 
Authors:  Fang WH, Hu LL, Yang XL, Hu K, Liang SC, Zhou S
 
Drug:  Enrofloxacin
 
Fish species:  Crab, mud
 
Date:  2008
 
t1/2-hr:  79
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  135
 
Ave Water temp (°C):  19
 
Water:  Brackish
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  t1/2 alpha=4.5, Cmax=7.26 ug/ml, tmax 6 h, t1/2ka=3.7 h, AUC 636 mg/L/h. Residues0.5 h=1.4, 1h=1.8, 2h=2.3, 4h=4.4, 6h=7.3, 12h=5.7, 24h=4.9, 48h=3.9, 96 h=2.4, 144h=1.5, 192 h=0.99. MRT102.5 h.
 
Cl:  0.016
 
Vd:  1.637
 
Citation:  J Fish Diseases 31:171-176
 
Link:  http://fdamedlibmd.library.ingentaconnect.com/content/bsc/jfd/2008/00000031/00000003/art00002  Opens a new window
 
Genus Species:  Scylla serrata
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  79.1 h
 
Wt gm-detail:  120-150 g
 
Water temp (°C)-detail:  19+/-0.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Fang WH, Hu LL, Yang XL, Hu K, Liang SC, Zhou S
 
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