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U.S. Department of Health and Human Services

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Title:  Bioconcentration and metabolism of Thiabendazole [2-(4-Thiazolyl)-1H-benzimidazole] in Bluegill sunfish, Lepomis macrochirus.
 
Authors:  VandenHeuvel WJA, Wislocki PG, Hirsch MP, Porter NK, Ambrose RT, Robillard KA
 
Drug:  Thiabendazole
 
Fish species:  Bluegill
 
Date:  1997
 
t1/2-hr:  72
 
est:  est
 
Sample:  whole body
 
Ave Weight (gm):  4
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  2.24 ppb 28 d
 
Route:  BATH
 
Comments:  14-C-Thiabendazole. Bioconcentration factor 96.5 clearance >95% by 14 d. Residues ng equiv/g uptake: d0=8, d3=193, d7=184, d14=159, 21d=187, 28d=199 during exposure, depuration- d1=251, d3=81, d7=16, d10=11, d14=11.
 
Metabolites:  5-HO-TBZ, unidentified metabolite.
 
Citation:  J. Agricultural Food Chemistry 45:985-989
 
Link:  http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/1997/45/i03/abs/jf9602333.html  Opens a new window
 
Genus Species:  Lepomis macrochirus
 
Drug Class:  Antiparasitic-Benzimidazole
 
t1/2-detail:  <72 h est
 
Wt gm-detail:  3-5 g
 
Water temp (°C)-detail:  22+/-2 C
 
Dosage-detail:  2.24+/-0.09 ug/l for 28 d
 
Method:  HPLC-Rad
 
Authors-red:  VandenHeuvel WJA, Wislocki PG, Hirsch MP, Porter NK, Ambrose RT, Robillard KA
 
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