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U.S. Department of Health and Human Services

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Title:  Pharmacokinetic studies of florfenicol in Koi carp and Threespot gourami Trichogaster trichopterus after oral and intramuscular treatment
 
Authors:  Yanong RPE, Curtis EW, Simmons R,  Bhattaram VA,  Gopalakrishnan M, Ketabi N, Nagaraja NV, Derendorf H
 
Drug:  Florfenicol
 
Fish species:  Gourami, three spot
 
Date:  2005
 
t1/2-hr:  4
 
Sample:  blood, plasma
 
Ave Weight (gm):  19
 
Ave Water temp (°C):  24
 
Water:  Freshwater
 
Dosage:  50 mg/kg sd
 
Route:  PO
 
Comments:  Ka- absorption 1.2/h, Non compartmental analysis C max=2.6h, Tmax=5 h, AUC=27.5ug/h//ml, t1/2=6.6 h.
 
Cl:  0.3 L/kg/h
 
Vd:  2.0 L/kg
 
Citation:  J. Aquatic Animal Health 17:129-137
 
Link:  http://afs.allenpress.com/perlserv/?request=get-abstract&doi=10.1577%2FH03-065.1  Opens a new window
 
Genus Species:  Trichopodus trichopterus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  4.2
 
Wt gm-detail:  19+/-3 g
 
Water temp (°C)-detail:  23-25 C
 
Dosage-detail:  50 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Yanong RPE, Curtis EW, Simmons R,  Bhattaram VA,  Gopalakrishnan M, Ketabi N, Nagaraja NV, Derendorf H
 
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