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U.S. Department of Health and Human Services

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Title:  Uptake of erythromycin by first-feeding sockeye-salmon, Oncorhynchus nerka (Walbaum), fed live or freeze-dried enriched adult Artemia or medicated pellets.
 
Authors:  Cook MA, Rust MB, Massee K, Majack T, Peterson ME
 
Drug:  Erythromycin
 
Fish species:  Salmon, sockeye
 
Date:  2003
 
Sample:  whole body
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  13
 
Water:  Freshwater
 
Dosage:  1100 mg/kg 35 d
 
Route:  PO
 
Comments:  Pellets. Erythromycin concentration in tissues of the fish fed live Artemia (residue=25 ug/ml) was higher than those fed pellets (0.70 ug/ml). Uptake of bioencapsulated erythromycin from Artemia has a greater uptake than from pellets. Erythromycin still detectable in tissue 21d (0.70 ug/ml) after drug withdrawal, but absent after 35d. t 1/2 difficult to estimate since levels are so low.
 
Citation:  J. Fish Diseases 26:277-285
 
Dep-time:  < 35 d
 
Link:  http://www.ncbi.nlm.nih.gov/pubmed/12962236  Opens a new window
 
Genus Species:  Oncorhynchus nerka
 
Drug Class:  Antibiotic-Macrolide
 
t1/2-detail:  levels too low to estimate t1/2
 
Wt gm-detail:  fry
 
Water temp (°C)-detail:  12.4-13.7 C
 
Dosage-detail:  1100 ug/g for 35 d
 
Method:  Micro
 
Authors-red:  Cook MA, Rust MB, Massee K, Majack T, Peterson ME
 
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