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U.S. Department of Health and Human Services

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Title:  A single-dose pharmacokinetics study of oxolinic acid and vetoquinol, an oxolinic acid ester, in cod, Gadus morhua L., held in sea water at 8 C and in vitro antibacterial activity of oxolinic acid against Vibrio anguillarum strains isolated from diseased cod.
 
Authors:  Samuelsen OB, Bergh O, Ervik A (2003b)
 
Drug:  Oxolinic acid
 
Fish species:  Cod, Atlantic
 
Date:  2003
 
t1/2-hr:  84
 
Sample:  blood, plasma
 
Ave Weight (gm):  125
 
Ave Water temp (°C):  8
 
Water:  Saltwater
 
Dosage:  12.5 mg/kg sd
 
Route:  IV
 
Comments:  Bioavailability=55%, t1/2 alpha=1.3 h.
 
Cl:  0.047 L/kg/h
 
Vd:  5.5 L/kg
 
Citation:  J. Fish Diseases 26:339-347
 
Link:  http://dx.doi.org/10.1046/j.1365-2761.2003.00466.x  Opens a new window
 
Genus Species:  Gadus morhua
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  84 h
 
Wt gm-detail:  100-150g
 
Water temp (°C)-detail:  8 +/- 0.5 C
 
Dosage-detail:  12.5 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Samuelsen OB, Bergh O, Ervik A (2003b)
 
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