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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetic modeling of the dogfish shark (Squalus acanthias): Distribution and urinary and biliary excretion of phenol red and its glucuronide.
 
Authors:  Bungay PM, Dedrick RL, Guarino AM
 
Drug:  Phenol red
 
Fish species:  Shark, picked dogfish
 
Date:  1976
 
t1/2-hr:  3
 
est:  est
 
Sample:  blood, plasma
 
Ave Weight (gm):  5000
 
Ave Water temp (°C):  0
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IV
 
Comments:  No metabolites found. T 1/2 est from graph.
 
Protein binding:  at 4 hrs ave 67%
 
Citation:  J. Pharmacokinetics and Biopharmaceutics 4:5:377-388.
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1003326  Opens a new window
 
Genus Species:  Squalus acanthias
 
Drug Class:  Organic-Phenol
 
t1/2-detail:  3 h est
 
Wt gm-detail:  3000-7000 g
 
Water temp (°C)-detail:  Not specified
 
Dosage-detail:  10 mg/kg sd
 
Method:  Absorbance
 
Authors-red:  Bungay PM, Dedrick RL, Guarino AM
 
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