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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus).
Authors:  Grondel JL, Nouws JFM, Schutte AR, Driessens F
Drug:  Oxytetracycline
Fish species:  Catfish, North African
Date:  1989
t1/2-hr:  75
Sample:  blood, plasma
Ave Weight (gm):  293
Ave Water temp (°C):  25
Water:  Freshwater
Dosage:  60 mg/kg sd
Route:  IM
Comments:  Bioavailability 86%. Swelling at site of injection (dorsal region). Blood samples taken from caudal vein (0.2 ml). Cmax (mean max plasma concentration) =43.4 ug/ml at 7h.
Citation:  J. Veterinary Pharmacology and Therapeutics 12:157-162
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2746722  Opens a new window
Genus Species:  Clarias gariepinus
Drug Class:  Antibiotic-Tetracycline
t1/2-detail:  74.7+/-10.1 h
Wt gm-detail:  293+/-45 g
Water temp (°C)-detail:  25 C
Dosage-detail:  60 mg/kg sd
Method:  Micro
Authors-red:  Grondel JL, Nouws JFM, Schutte AR, Driessens F