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Title:
Pharmacokinetic and tissue distribution study of oxytetracycline in rainbow trout following bolus intravenous administration.
Authors:
Black WD, Ferguson HW, Byrne P, Claxton MJ
Drug:
Oxytetracycline
Fish species:
Trout, rainbow
Date:
1991
t1/2-hr:
82
Sample:
blood, serum
Ave Weight (gm):
375
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
5 mg/kg sd
Route:
IV
Comments:
Serum [] 96h post = 0.52+/-0.17mg/g; takes 408-654h for 97% of drug to disappear dep on 5 t1/2 or max t1/2 used. AUC 196.9 ug.h/ml
Cl:
0.025 L/kg/h
Vc:
0.019 L/kg
Vd:
2.99 L/kg
Citation:
J. Veterinary Pharmacology and Therapeutics 14:351-358
Dep-time:
408 h
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1774812&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
81.5h
Wt gm-detail:
300-450g
Water temp (°C)-detail:
10+/-0.5C
Dosage-detail:
5 mg/kg sd
Method:
Micro
Authors-red:
Black WD, Ferguson HW, Byrne P, Claxton MJ
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