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U.S. Department of Health and Human Services

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Title:  Pharmacokinetic and tissue distribution study of oxytetracycline in rainbow trout following bolus intravenous administration.
 
Authors:  Black WD, Ferguson HW, Byrne P, Claxton MJ
 
Drug:  Oxytetracycline
 
Fish species:  Trout, rainbow
 
Date:  1991
 
t1/2-hr:  82
 
Sample:  blood, serum
 
Ave Weight (gm):  375
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  5 mg/kg sd
 
Route:  IV
 
Comments:  Serum [] 96h post = 0.52+/-0.17mg/g; takes 408-654h for 97% of drug to disappear dep on 5 t1/2 or max t1/2 used. AUC 196.9 ug.h/ml
 
Cl:  0.025 L/kg/h
 
Vc:  0.019 L/kg
 
Vd:  2.99 L/kg
 
Citation:  J. Veterinary Pharmacology and Therapeutics 14:351-358
 
Dep-time:  408 h
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1774812&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  81.5h
 
Wt gm-detail:  300-450g
 
Water temp (°C)-detail:  10+/-0.5C
 
Dosage-detail:  5 mg/kg sd
 
Method:  Micro
 
Authors-red:  Black WD, Ferguson HW, Byrne P, Claxton MJ
 
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