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PhishPharm - Detail

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Title:  Pharmacokinetics of oxolinic acid in sea-bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection.
Authors:  Poher I, Blanc G, Loussouarn S
Drug:  Oxolinic acid
Fish species:  Seabass, European
Date:  1997
t1/2-hr:  87
Sample:  blood, plasma
Ave Weight (gm):  100
Ave Water temp (°C):  15
Water:  Saltwater
Dosage:  10 mg/kg sd
Route:  IV
Comments:  Distribution t1/2=0.69h; Vd= 2.55L/kg; Vc= 0.4L/kg Alpha t 1/2 = 0.69 h. Compared bioassay with HPLC - both similar.
Cl:  0.066L/kg/h
Vc:  0.4L/kg
Vd:  2.55L/kg
Citation:  J. Veterinary Pharmacology and Therapeutics 20:267-275
Link:  http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1365-2885.1997.00062.x&area=production&prevSearch=allfield%3A%28Poher%29  Opens a new window
Genus Species:  Dicentrarchus labrax
Drug Class:  Antibiotic-Quinolone
t1/2-detail:  86.6 h
Wt gm-detail:  100+/-10g
Water temp (°C)-detail:  15.2+/-0.2C
Dosage-detail:  10 mg/kg sd
Method:  HPLC, bioassay
Authors-red:  Poher I, Blanc G, Loussouarn S