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U.S. Department of Health and Human Services

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Title:  Pharmokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus).
 
Authors:  Park BK, Lim JH, Kim MS, Yun HI
 
Drug:  Florfenicol
 
Fish species:  Catfish, amur
 
Date:  2006
 
t1/2-hr:  11
 
Sample:  blood, plasma
 
Ave Weight (gm):  280
 
Ave Water temp (°C):  24
 
Water:  Freshwater
 
Dosage:  20 mg/kg sd
 
Route:  IV
 
Comments:  Plasma florfenicol and florfenicol amine concentration were analyzed for eash fish. Fish were deeply anesthetized with MS-222. Florfenicol: AUC=269.64 mg*h/L, MRT=12.69 h. Florfenicol amine: T1/2=14h, AUC=70.00 mg*h/L, Tmax=0.50 h, Cmax=3.91 mg/L, MRT=17.65 h, Metabolic ratio=25.96%.
 
Cl:  0.07 L/kg/h
 
Vd:  1.09 L/kg
 
Metabolites:  Florfenicol amine
 
Citation:  J. Veterinary Pharmacology and Therapeutics 29:37-40
 
Link:  http://dx.doi.org/10.1111/j.1365-2885.2006.00709.x  Opens a new window
 
Genus Species:  Silurus asotus
 
Drug Class:  Antiobiotic-phenicol
 
t1/2-detail:  Metabolite:14.03+/- 1.82 h. Florfenicol:11.12+/- 1.03 h
 
Wt gm-detail:  280.4+/-20.8 g
 
Water temp (°C)-detail:  23.5+/-1.7C
 
Dosage-detail:  20 mg/kg sd
 
Method:  LC/MS
 
Authors-red:  Park BK, Lim JH, Kim MS, Yun HI
 
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