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Title:
Metabolism and depletion of albendazole in the muscle tissue of channel catfish following oral treatment.
Authors:
Shaikh B, Rummel N, Gieseker C, Reimschuessel R
Drug:
Albendazole
Fish species:
Catfish, channel
Date:
2006
t1/2-hr:
8
est:
est
Sample:
muscle
Ave Weight (gm):
896
Ave Water temp (°C):
25
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
PO
Comments:
Residues for ABZ 8h=11 ug/kg, 16h=ND, these results suggest that ABZ is absorbed poorly from the GI tract, and the absorbed drug is excreted rapidly in catfish. Unlike other species, no aminosulfone metabolite was detected. T1/2 field refers to parent (ABZ).
Metabolites:
ABZ-SO, ABZ-SO2, ABZ-2NH2SO2
Citation:
J. Veterinary Pharmacology and Therapeutics 29:525-530
Link:
http://onlinelibrary.wiley.com/doi/10.1046/j.0140-7783.2003.00534.x/abstract
Genus Species:
Ictalurus punctatus
Drug Class:
Antiparasitic-Benzimidazole
t1/2-detail:
less than 8 h est
Wt gm-detail:
896+/-114 g
Water temp (°C)-detail:
25 +/-2 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Shaikh B, Rummel N, Gieseker C, Reimschuessel R
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