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Title:
Pharmacokinetics of proflavine in rainbow trout.
Authors:
Yu Z, Abbas A, Vick A, Doddapaneni S, Hayton WL
Drug:
Proflavine
Fish species:
Trout, rainbow
Date:
1994
t1/2-hr:
28
Sample:
blood, plasma
Ave Weight (gm):
0
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
0.7 mg/kg sd
Route:
IVC
Comments:
Total body clearnace very large considering cardiac output, indicating possible excretion via gills. Proflavine (14)C.
Cl:
1.4 L/kg/h
Vd:
35 L/kg
Metabolites:
Unidentified metabolite
Citation:
Pharmaceutical Research 11:10:S-384
Link:
none
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Dye
t1/2-detail:
28 h
Wt gm-detail:
Not specified
Water temp (°C)-detail:
12 C
Dosage-detail:
0.7 mg/kg sd
Method:
HPLC/RP, HPLC-Rad
Authors-red:
Yu Z, Abbas A, Vick A, Doddapaneni S, Hayton WL
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