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Title:  Pharmacokinetics of acriflavine and its metabolite in rainbow trout.
Authors:  Yu Z, Vick A, Hayton WL
Drug:  Acriflavine
Fish species:  Trout, rainbow
Date:  1995
t1/2-hr:  94
Sample:  blood, plasma
Ave Weight (gm):  0
Ave Water temp (°C):  12
Water:  Freshwater
Dosage:  1.825 mg/kg sd
Route:  IVC
Comments:  Long t1/2 of acriflavine and metabolite due to large Vd. Acriflavine (14)C
Cl:  2.02 L/kg/h
Vd:  132 L/kg
Citation:  Pharmaceutical Research 12:9:S-347
Link:  none  Opens a new window
Genus Species:  Oncorhynchus mykiss
Drug Class:  Organic-Dye
t1/2-detail:  96 h
Wt gm-detail:  Not specified
Water temp (°C)-detail:  12 C
Dosage-detail:  1.75-1.90 mg/kg sd
Method:  HPLC/RP, HPLC-Rad
Authors-red:  Yu Z, Vick A, Hayton WL