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U.S. Department of Health and Human Services

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Title:  Toxicokinetics of parathion and paraoxon in rainbow trout after intravascular administration and water exposure.
 
Authors:  Abbas R, Schultz IR, Doddapaneni S, Hayton WL
 
Drug:  Parathion
 
Fish species:  Trout, rainbow
 
Date:  1996
 
t1/2-hr:  56
 
Sample:  blood, plasma
 
Ave Weight (gm):  440
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  Paraoxon is a metabolite of parathion; Vd for parathion = 1370 ml/kg. Catheterized fish.
 
Protein binding:  0.98
 
Cl:  0.021 L/kg/h
 
Vd:  1.370 L/kg
 
Metabolites:  Paraoxon
 
Citation:  Toxicology and Applied Pharmacology 136:194-199
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8560474&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Phosphorus-Pesticide
 
t1/2-detail:  56.1 h
 
Wt gm-detail:  1330-550 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  GC
 
Authors-red:  Abbas R, Schultz IR, Doddapaneni S, Hayton WL
 
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