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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Uptake and release of naphthalene and its metabolites in skin and epidermal mucus of salmonids.
 
Authors:  Varanasi U, Uhler M, Stranahan SI
 
Drug:  Naphthalene
 
Fish species:  Trout, rainbow
 
Date:  1978
 
t1/2-hr:  72
 
est:  est
 
Sample:  skin
 
Ave Weight (gm):  150
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  see comments
 
Route:  BATH
 
Comments:  Dose - 30.1 mg (20mCi) [3H]napthtalene + 37.7 mg cold naphthalene/7 ml 95% ethanol + 0.942L water. In the water immersion study, after 48 h expsure 4232, 72 h exposure 2103, after 72 hr of depuration, levels of naphthalene was 223 ppb at 72 hrs and metabolites was 272.5. 24 h 4232 ppb at 48 h, and 2103 at 72 h, (est)
 
Citation:  Toxicology and Applied Pharmacology 44:277-289
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=675702&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Hydrocarbon
 
t1/2-detail:  24 h (est)4232 ppb at 48 h, and 2103 at 72 h
 
Wt gm-detail:  150 +/- 50g
 
Water temp (°C)-detail:  10+/-C
 
Dosage-detail:  30.1 mg (20mCi) [3H]napthtalene + 37.7 mg cold naphthalene/7 ml 95% ethanol + 0.942L water
 
Method:  Rad
 
Authors-red:  Varanasi U, Uhler M, Stranahan SI
 
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