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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Metabolism and disposition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in rainbow trout.
 
Authors:  Kleeman JM, Olson JR, Chen SM, Peterson RE (1986a)
 
Drug:  TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
 
Fish species:  Trout, rainbow
 
Date:  1986
 
t1/2-hr:  2520
 
Sample:  whole body
 
Ave Weight (gm):  10
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  494 pg TCDD/g diet 13 wks
 
Route:  PO
 
Comments:  Fed 3% body weight/ day 18+/-2C- t1/2 - 15 +/- 4 week, TCDD(3H)
 
Metabolites:  Glucuronic acid conjugate
 
Citation:  Toxicology and Applied Pharmacology 83:391-401
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3705069&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Chlorinated-Pesticide
 
t1/2-detail:  15 +/- 4 weeks
 
Wt gm-detail:  7-14 g
 
Water temp (°C)-detail:  18 +/- 2 C
 
Dosage-detail:  494 pg TCDD/g diet for 13 wks (494 ppt) (300 uCi, 28 Ci/ mmol)
 
Method:  Rad
 
Authors-red:  Kleeman JM, Olson JR, Chen SM, Peterson RE (1986a)
 
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