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Title:
Pharmacokinetics of sulphadimidine in carp (Cyprinus carpio L.) and rainbow trout (Salmo gairdneri Richardson) acclimated at two different temperature levels.
Authors:
Van Ginneken VJTh., Nouws JFM, Grondel JL, Driessens F, Degen M
Drug:
Sulfadimidine
Fish species:
Carp, common
Date:
1991
t1/2-hr:
28
Sample:
blood, plasma
Ave Weight (gm):
421
Ave Water temp (°C):
20
Water:
Freshwater
Dosage:
100 mg/kg sd
Route:
IV
Comments:
N4-SDM=5.62+/-0.77%, SCH2OH= 0.67+/-0.44%. T1/2 at 10 C = 50.3 vs 20 C= 25.6 h- approx 1 day difference due to temperature.
Cl:
0.02466 L/kg/h
Vd:
0.90+/-0.07 L/kg
Metabolites:
N4-A-sulfadimidine, SCH2OH
Citation:
Veterinary Quarterly 13:2:88-96
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1882494&dopt=Abstract
Genus Species:
Cyprinus carpio
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
25.6+/-2.6h
Wt gm-detail:
421+/-44g
Water temp (°C)-detail:
20C
Dosage-detail:
100 mg/kg sd
Method:
HPLC
Authors-red:
Van Ginneken VJTh., Nouws JFM, Grondel JL, Driessens F, Degen M
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