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U.S. Department of Health and Human Services

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Title:  Metabolism and elimination of benzocaine by rainbow trout, Oncorhynchus mykiss.
 
Authors:  Meinertz JR, Gingerich WH, Allen JL
 
Drug:  Benzocaine
 
Fish species:  Trout, rainbow
 
Date:  1991
 
Sample:  urine
 
Ave Weight (gm):  650
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  20.8 ug/kg sd
 
Route:  IVC
 
Comments:  Benzocaine eliminated primarily through the gills, renal biliary pathways were less significant elimination routes. Contained 9.0+/-2.6% of the dose at 24h.
 
Metabolites:  Para-aminobenzoic acid, N-acetylated para-aminobenzoic acid
 
Citation:  Xenobiotica 21:4:525-533
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1897251  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Anesthetic-Benzocaine
 
Wt gm-detail:  595-704 g
 
Water temp (°C)-detail:  12+/-0.9 C
 
Dosage-detail:  20.8 ug/kg sd
 
Method:  HPLC-Rad
 
Authors-red:  Meinertz JR, Gingerich WH, Allen JL
 
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