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U.S. Department of Health and Human Services

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Title:  Disposition kinetics of trimethoprim in rainbow trout (Oncorhynchus mykiss).
 
Authors:  Tan WP, Wall RA
 
Drug:  Trimethoprim
 
Fish species:  Trout, rainbow
 
Date:  1995
 
t1/2-hr:  36
 
Sample:  blood, plasma
 
Ave Weight (gm):  485
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  t 1/2 alpha= 0.13 h, beta 1.26, gamma 36.1 h. Rapid drop during first few hours, then a longer terminal elimination phase. Compartmental analysis
 
Vc:  0.248 L/kg
 
Vd:  5.98 L/kg
 
Citation:  Xenobiotica 25:3:315-329
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7618357  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  alpha= 0.13 h, beta 1.26, gamma 36.1 h
 
Wt gm-detail:  390-580 g
 
Water temp (°C)-detail:  10+/-0.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC/RP, HPLC
 
Authors-red:  Tan WP, Wall RA
 
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