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Title:
Disposition kinetics of trimethoprim in rainbow trout (Oncorhynchus mykiss).
Authors:
Tan WP, Wall RA
Drug:
Trimethoprim
Fish species:
Trout, rainbow
Date:
1995
t1/2-hr:
37
Sample:
blood, plasma
Ave Weight (gm):
485
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
IVC
Comments:
Rapid drop during first few hours, then a longer terminal elimination phase. AUC 239 umol-h/l. Non-compartmental analysis
Cl:
0.144 L/kg/h
Vd:
6.75 L/kg
Citation:
Xenobiotica 25:3:315-329
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7618357
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
37 h
Wt gm-detail:
390-580 g
Water temp (°C)-detail:
10+/-0.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC/RP, HPLC
Authors-red:
Tan WP, Wall RA
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