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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Excretion of phenol red and its glucuronide in the dogfish shark.
Authors:  Guarino AM, Anderson JB
Drug:  Phenol red
Fish species:  Shark, picked dogfish
Date:  1976
t1/2-hr:  8
Sample:  blood, plasma
Ave Weight (gm):  5000
Ave Water temp (°C):  0
Water:  Saltwater
Dosage:  10 mg/kg sd
Route:  IV
Comments:  Level in plasma was below the limit of detection, 5 µg/ml, after 12 hhas chart on the effect of probenecid pre-treatment on the distribution of phenol red and its glucuronide; initial t1/2= 46 min, ambient temp-seawater - Maine.
Protein binding:  0.666
Metabolites:  Glucuronic acid conjugate
Citation:  Xenobiotica 6:1:1-13
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1274366&dopt=Abstract  Opens a new window
Genus Species:  Squalus acanthias
Drug Class:  Organic-Phenol
t1/2-detail:  8.3 h
Wt gm-detail:  3-7 kg
Water temp (°C)-detail:  Not Specified
Dosage-detail:  10 mg/kg sd
Method:  Absorbance
Authors-red:  Guarino AM, Anderson JB