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Title:
Excretion of phenol red and its glucuronide in the dogfish shark.
Authors:
Guarino AM, Anderson JB
Drug:
Phenol red
Fish species:
Shark, picked dogfish
Date:
1976
t1/2-hr:
8
Sample:
blood, plasma
Ave Weight (gm):
5000
Ave Water temp (°C):
0
Water:
Saltwater
Dosage:
10 mg/kg sd
Route:
IV
Comments:
Level in plasma was below the limit of detection, 5 µg/ml, after 12 hhas chart on the effect of probenecid pre-treatment on the distribution of phenol red and its glucuronide; initial t1/2= 46 min, ambient temp-seawater - Maine.
Protein binding:
0.666
Metabolites:
Glucuronic acid conjugate
Citation:
Xenobiotica 6:1:1-13
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1274366&dopt=Abstract
Genus Species:
Squalus acanthias
Drug Class:
Organic-Phenol
t1/2-detail:
8.3 h
Wt gm-detail:
3-7 kg
Water temp (°C)-detail:
Not Specified
Dosage-detail:
10 mg/kg sd
Method:
Absorbance
Authors-red:
Guarino AM, Anderson JB
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