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U.S. Department of Health and Human Services

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TITLE:  Antimicrobial drug resistance in Escherichia coli from humans and food animals, United States, 1950-2002
 
AUTHORS:  Tadesse DA;Zhao S;Tong E;Ayers S;Singh A;Bartholomew MJ;McDermott PF;
 
YEAR:  2012
 
JOURNAL ABBREV:  Emerg Infect Dis
 
MONTH:  May
 
TYPE:  JOUR
 
REFMAN INDEX:  635
 
JOURNAL FULL:  Emerging infectious diseases
 
VOLUME:  18
 
ISSUE:  5
 
START PAGE:  741
 
END PAGE:  749
 
KEYWORDS:  Ampicillin;Animals;antimicrobial;Cattle;Chickens;COLI;drug;drug classes;Drug Resistance;DRUGS;Escherichia coli;ESCHERICHIA-COLI;Food;FOOD ANIMALS;GENTAMICIN;Humans;Maryland;multidrug resistance;MULTIDRUG-RESISTANCE;Phenotype;pigs;STRAIN;STRAINS;Streptomycin;SUSCEPTIBILITY;Tetracycline;United States;UNITED-STATES;
 
ABSTRACT:  We conducted a retrospective study of Escherichia coli isolates recovered from human and food animal samples during 1950-2002 to assess historical changes in antimicrobial drug resistance. A total of 1,729 E. coli isolates (983 from humans, 323 from cattle, 138 from chickens, and 285 from pigs) were tested for susceptibility to 15 antimicrobial drugs. A significant upward trend in resistance was observed for ampicillin (p<0.001), sulfonamide (p<0.001), and tetracycline (p<0.001). Animal strains showed increased resistance to 11/15 antimicrobial agents, including ampicillin (p<0.001), sulfonamide (p<0.01), and gentamicin (p<0.001). Multidrug resistance (>/=3 antimicrobial drug classes) in E. coli increased from 7.2% during the 1950s to 63.6% during the 2000s. The most frequent co-resistant phenotype observed was to tetracycline and streptomycin (29.7%), followed by tetracycline and sulfonamide (29.0%). These data describe the evolution of resistance after introduction of new antimicrobial agents into clinical medicine and help explain the range of resistance in modern E. coli isolates
 
AFFILIATIONS:  Food and Drug Administration, Laurel, Maryland 20708, USA
 
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