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U.S. Department of Health and Human Services

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TITLE:  Bioaccumulation of cyanuric acid in edible tissues of shrimp following experimental feeding
AUTHORS:  Karbiwnyk CM;Williams RR;Andersen WC;Turnipseed SB;Madson MR;Miller KE;Reimschuessel R;
YEAR:  2010
JOURNAL FULL:  Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
ISSUE:  12
END PAGE:  1664
KEYWORDS:  analysis;Aquaculture;Body Weight;CATFISH;DEPOSITION;Diet;drug;DRUGS;exposure;Feed;FISH;fish and fish products;Food;Food Chain;LC;liquid chromatography-tandem mass spectrometry;LIQUID-CHROMATOGRAPHY;Mass Spectrometry;MASS-SPECTROMETRY;MELAMINE CONTAMINATED FEED;MS;pigs;process contaminants;RENAL-FAILURE;RESIDUE;Residue depletion;residues;TISSUE;TISSUES;Trout;urine;WEIGHT;
ABSTRACT:  Due to concerns that cyanuric acid (CYA)-contaminated feed had been used in aquaculture and could enter the human food chain, a method to quantify CYA residues in the edible tissues of fish and shrimp was previously developed and validated. This paper provides further data on the deliberate feeding of CYA to shrimp to determine the extent of residue accumulation in edible tissue. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed for the analysis of CYA in shrimp tissue. Edible tissue of shrimp fed 1666 or 3333 mg kg-1 CYA in their diet (approximately 55 and 124 mg kg-1 body weight) contained 0.767 and 0.406 mg kg-1 CYA, respectively. The residue levels are below the World Health Organization (WHO) tolerable daily intake level for CYA and are generally considered unlikely to pose a human health risk
AFFILIATIONS:  US FDA, Anim Drugs Res Ctr, Denver, CO 80225 USAUniv Arizona, Environm Res Lab, Tucson, AZ 85756 USAUS FDA, Denver Dist Lab, Denver, CO 80225 USAUniv Denver, Dept Chem & Biochem, Denver, CO 80208 USAUS FDA, Ctr Vet Med, Laurel, MD 20708 USA