• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

CVM Publications - Detail

  • Print
  • Share
  • E-mail
-
 
TITLE:  Residue depletion of albendazole and its metabolites in the muscle tissue of large mouth and hybrid striped bass after oral administration
 
AUTHORS:  Shaikh B;Rummel N;Gieseker C;Cheely CS;Reimschuessel R;
 
YEAR:  2009
 
MONTH:  Nov
 
TYPE:  JOUR
 
REFMAN INDEX:  591
 
JOURNAL FULL:  Journal of Chromatography A
 
VOLUME:  1216
 
ISSUE:  46
 
START PAGE:  8173
 
END PAGE:  8176
 
KEYWORDS:  Albendazole;Aquaculture;Bass;Chromatography;FISH;growth;HPLC;Hybrid striped bass;Large mouth bass;LIQUID-CHROMATOGRAPHY;metabolism;MUSCLE;PERFORMANCE;RESIDUE;Residue depletion;SINGLE;Skin;Striped bass;TISSUE;TISSUES;
 
ABSTRACT:  The residue depletion profiles of albendazole (ABZ) and its major metabolites: albendazole sulfoxide (ABZ-SO), albendazole sulfone (ABZ-SO2) and albendazole aminosulfone (ABZ-2-NH2SO2) were studied in the muscle tissues of large mouth (LMB) and hybrid striped bass (HSB). A single oral dose of 10 mg/kg albendazole was given to the two fish species via infra-gastric tube. The muscle tissues with adhering skin were collected at 8, 16, 24, 48, 72, 96 and 120 h post dose from both species. The samples were homogenized in dry ice and subjected to extraction and cleanup procedures. The final sample extracts were analyzed by high performance liquid chromatography. The results indicate that both ABZ and its pharmacologically active metabolite ABZ-SO were retained longer in LMB than in HSB after oral treatment. Albendazole was detectable until 8 h or 6.7 degree days (degrees D) and 48h (40 degrees D) in HSB and LMB, respectively. However, ABZ-SO was detectable up to 48 h (40 degrees D) and 96 h (80 degrees D) in HSB and LMB, respectively. Among the inactive metabolites, ABZ-SO2 was present in both fish species; however. ABZ-2-NH2SO2 was detected only in LMB. Published by Elsevier B.V
 
AFFILIATIONS:  US FDA, Ctr Vet Med, Res Off, Laurel, MD 20708 USA
 
-
-