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TITLE:  Residue depletion of nitrofuran drugs and their tissue-bound metabolites in channel catfish (Ictalurus punctatus) after oral dosing
AUTHORS:  Chu PS;Lopez MI;Abraham A;El Said KR;Plakas SM;
YEAR:  2008
JOURNAL ABBREV:  J Agric Food Chem
JOURNAL FULL:  Journal of agricultural and food chemistry
ISSUE:  17
END PAGE:  8034
KEYWORDS:  administration & dosage;analysis;Animals;Anti-Infective Agents;Body Weight;chemistry;Food;Ictaluridae;Kinetics;Maryland;metabolism;Muscles;Nitrofurans;pharmacokinetics;veterinary;Veterinary Medicine;
ABSTRACT:  The depletion of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin and their tissue-bound metabolites [3-amino-2-oxazolidinone (AOZ), semicarbazide (SC), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), and 1-aminohydantoin (AH), respectively] were examined in the muscle of channel catfish following oral dosing (1 mg/kg body weight). Parent drugs were measurable in muscle within 2 h. Peak levels were found at 4 h for furazolidone (30.4 ng/g) and at 12 h for nitrofurazone, furaltadone, and nitrofurantoin (104, 35.2, and 9.8 ng/g respectively). Parent drugs were rapidly eliminated from muscle, and tissue concentrations fell below the limit of detection (1 ng/g) at 96 h. Peak levels of tissue-bound AMOZ and AOZ (46.8 and 33.7 ng/g respectively) were measured at 12 h, and of SC and AH (31.1 and 9.1 ng/g, respectively) at 24 h. Tissue-bound metabolites were measurable for up to 56 days postdose. These results support the use of tissue-bound metabolites as target analytes for monitoring nitrofuran drugs in channel catfish
AFFILIATIONS:  Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. pak.chu@fda.hhs.gov