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U.S. Department of Health and Human Services

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TITLE:  Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
 
AUTHORS:  McDermott PF;Bodeis SM;English LL;White DG;Walker RD;Zhao S;Simjee S;Wagner DD;
 
YEAR:  2002
 
JOURNAL ABBREV:  J Infect Dis
 
MONTH:  Mar
 
TYPE:  JOUR
 
REFMAN INDEX:  247
 
JOURNAL FULL:  The Journal of infectious diseases
 
VOLUME:  185
 
ISSUE:  6
 
START PAGE:  837
 
END PAGE:  840
 
KEYWORDS:  Animals;Anti-Infective Agents;Campylobacter;Campylobacter jejuni;Chickens;Ciprofloxacin;drug effects;Drug Resistance,Bacterial;Fluoroquinolones;Food;Food Microbiology;Maryland;Microbial Sensitivity Tests;microbiology;pharmacology;Poultry;Research;therapy;United States;veterinary;Veterinary Medicine;
 
ABSTRACT:  Fluoroquinolones are commonly used to treat gastroenteritis caused by Campylobacter species. Domestically acquired fluoroquinolone-resistant Campylobacter infection has been documented recently in the United States. It has been proposed that the increase in resistance is due, in part, to the use of fluoroquinolones in poultry. In separate experiments, the effects of sarafloxacin and enrofloxacin treatment of Campylobacter jejuni-infected chickens on the development of ciprofloxacin resistance were measured. Fecal samples were collected before and after treatment and were cultured for C. jejuni. When enrofloxacin or sarafloxacin was used at US Food and Drug Administration-approved doses in broiler chickens, resistance developed rapidly and persisted in C. jejuni. MICs of ciprofloxacin increased from a base of 0.25 microg/mL to 32 microg/mL within the 5-day treatment time frame. These results show that the use of these drugs in chickens rapidly selects for resistant Campylobacter organisms and may result in less effective fluoroquinolone therapy for cases of human campylobacteriosis acquired from exposure to contaminated chicken
 
AFFILIATIONS:  Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA. pmcdermo@cvm.fda.gov
 
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