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TITLE:  Characterization of fluoroquinolone resistance among veterinary isolates of avian Escherichia coli
 
AUTHORS:  White DG;Piddock LJ;Maurer JJ;Zhao S;Ricci V;Thayer SG;
 
YEAR:  2000
 
JOURNAL ABBREV:  Antimicrob Agents Chemother
 
MONTH:  Oct
 
TYPE:  JOUR
 
REFMAN INDEX:  97
 
JOURNAL FULL:  Antimicrobial agents and chemotherapy
 
VOLUME:  44
 
ISSUE:  10
 
START PAGE:  2897
 
END PAGE:  2899
 
KEYWORDS:  analysis;Animals;Anti-Infective Agents;Dna;DNA Gyrase;DNA Topoisomerase IV;DNA Topoisomerases;DNA Topoisomerases,Type II;DNA,Bacterial;drug effects;epidemiology;Escherichia coli;Escherichia coli Infections;Fluoroquinolones;genetics;Georgia;microbiology;Mutation;Nalidixic Acid;pharmacology;Polymorphism,Restriction Fragment Length;Poultry;Poultry Diseases;Research;Reverse Transcriptase Polymerase Chain Reaction;veterinary;
 
ABSTRACT:  Fluoroquinolone-resistant avian Escherichia coli isolates from northern Georgia were investigated for gyrA and parC mutations. All isolates contained a mutation in GyrA replacing Ser83 with Leu; seven isolates also contained mutations replacing Asp87 with either Gly or Tyr. Random amplified polymorphic DNA analysis revealed that quinolone-resistant E. coli isolates were genetically diverse
 
AFFILIATIONS:  Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota, USA. dwhite@cvm.fda.gov
 
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