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TITLE:  Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis
 
AUTHORS:  Britt JS;Carson MC;von Bredow JD;Condon RJ;
 
YEAR:  1999
 
JOURNAL ABBREV:  J Am Vet Med Assoc
 
MONTH:  Sep
 
TYPE:  JOUR
 
REFMAN INDEX:  137
 
JOURNAL FULL:  Journal of the American Veterinary Medical Association
 
VOLUME:  215
 
ISSUE:  6
 
START PAGE:  833
 
END PAGE:  836
 
KEYWORDS:  analysis;Animals;Anti-Bacterial Agents;Cattle;Cattle Diseases;chemistry;Chromatography;Chromatography,High Pressure Liquid;Dermatitis;Drug Residues;drug therapy;Female;Foot Diseases;Hoof and Claw;Milk;Oxytetracycline;Papilloma;Tetracycline;therapeutic use;Treatment Outcome;veterinary;Veterinary Medicine;
 
ABSTRACT:  OBJECTIVE: To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline. DESIGN: Randomized controlled clinical trial. ANIMALS: 28 lactating Holstein cows with PDD. PROCEDURE: Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test. RESULTS: None of the cows in either treatment group had violative residues of oxytetracycline in milk samples. CONCLUSIONS AND CLINICAL RELEVANCE: Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk
 
AFFILIATIONS:  Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706-1102, USA
 
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