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TITLE:  Determination of desaminosulfamethazine, sulfamethazine, and N4-acetylsulfamethazine by gas chromatography with electron capture detection and confirmation by gas chromatography-chemical ionization mass spectrometry
 
AUTHORS:  Matusik JE;Guyer CG;Geleta JN;Barnes CJ;
 
YEAR:  1987
 
JOURNAL ABBREV:  J Assoc Off Anal Chem
 
MONTH:  May
 
TYPE:  JOUR
 
REFMAN INDEX:  368
 
JOURNAL FULL:  Journal - Association of Official Analytical Chemists
 
VOLUME:  70
 
ISSUE:  3
 
START PAGE:  546
 
END PAGE:  553
 
KEYWORDS:  analogs & derivatives;analysis;Animals;Capillaries;Cattle;Chromatography;Gas Chromatography-Mass Spectrometry;Indicators and Reagents;Liver;Mass Spectrometry;Meat;Sulfamethazine;Swine;
 
ABSTRACT:  An electron capture gas chromatographic method for the determination of sulfamethazine was modified to separate and quantitate simultaneously sulfamethazine and 2 of its metabolites, N4-acetylsulfamethazine and desaminosulfamethazine. The modified method was applied to incurred residues in a veal calf depletion study and to incurred residues in swine tissues. With capillary column gas chromatography-positive ion chemical ionization mass spectrometry, confirmation of the identities of incurred desaminosulfamethazine, N4-acetylsulfamethazine, and sulfamethazine in tissues was obtained from a single injection
 
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