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TITLE:  Characterization of a Pasteurella multocida (serotype B) bovine pneumonic pasteurellosis model and the effect of antimicrobials during peracute infection
 
AUTHORS:  Furrow RD;Parbuoni EL;McRae DT;Gaines SA;Guarnieri JA;Carnevale RA;April M;
 
YEAR:  1986
 
JOURNAL ABBREV:  J Vet Pharmacol Ther
 
MONTH:  Sep
 
TYPE:  JOUR
 
REFMAN INDEX:  387
 
JOURNAL FULL:  Journal of veterinary pharmacology and therapeutics
 
VOLUME:  9
 
ISSUE:  3
 
START PAGE:  264
 
END PAGE:  272
 
KEYWORDS:  Acute Disease;Animals;Animals,Newborn;Cattle;Cattle Diseases;drug therapy;Lung;Male;microbiology;Oxytetracycline;Pasteurella Infections;pathology;Pneumonia;Sulfadimethoxine;therapeutic use;veterinary;Water;
 
ABSTRACT:  A method to produce bovine pneumonic pasteurellosis for experimental purposes was studied and the clinical response of experimentally infected calves to selected antimicrobials was characterized. Male Holstein calves stressed with multiple hot and cold water applications followed by intratracheal inoculation of broth cultures of Pasteurella multocida serotype B developed acute clinical illness consistent with pneumonia. Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxytetracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. This disease model offers potential for use in pharmacokinetic and target tissue drug concentration studies and for dosage titration of drugs intended for treatment of bacterial pneumonias
 
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