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U.S. Department of Health and Human Services

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TITLE:  Review of chromatographic methods for chloramphenicol residues in milk, eggs, and tissues from food-producing animals
 
AUTHORS:  Allen EH;
 
YEAR:  1985
 
JOURNAL ABBREV:  J Assoc Off Anal Chem
 
MONTH:  Sep
 
TYPE:  JOUR
 
REFMAN INDEX:  380
 
JOURNAL FULL:  Journal - Association of Official Analytical Chemists
 
VOLUME:  68
 
ISSUE:  5
 
START PAGE:  990
 
END PAGE:  999
 
KEYWORDS:  analysis;Animals;Cattle;Chickens;Chloramphenicol;Chromatography;Chromatography,Liquid;Chromatography,Thin Layer;Eggs;Glucuronates;Humans;Meat;methods;Milk;Public Health;Swine;toxicity;United States;
 
ABSTRACT:  Although chloramphenicol is not approved for use in food-producing animals in the United States, this broad spectrum antibiotic has been widely used to treat diseases in such animals including the lactating dairy cow. Extremely low ophthalmologic doses of chloramphenicol are known to cause aplastic anemia in humans. The residues in meat, milk, and eggs intended for human consumption cause particular public health concern because the bone marrow aplasia is not dose dependent. Furthermore, chloramphenicol, a known inhibitor of protein synthesis, also retards erythropoiesis, a condition that is dose dependent and may cause allergic hypersensitivity reactions. This paper is a review of sensitive methods that use gas, liquid, thin layer, and simple column chromatography as both determinative and cleanup steps for detecting and quantitating chloramphenicol in edible animal tissues, milk, and eggs
 
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