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TITLE:  Comparison of three methods for determination of sulfamethazine in swine tissues: collaborative study
 
AUTHORS:  Malanoski AJ;Barnes CJ;Fazio T;
 
YEAR:  1981
 
JOURNAL ABBREV:  J Assoc Off Anal Chem
 
MONTH:  Nov
 
TYPE:  JOUR
 
REFMAN INDEX:  477
 
JOURNAL FULL:  Journal - Association of Official Analytical Chemists
 
VOLUME:  64
 
ISSUE:  6
 
START PAGE:  1386
 
END PAGE:  1391
 
KEYWORDS:  analysis;Animals;Chromatography,Gas;Colorimetry;Gas Chromatography-Mass Spectrometry;Liver;Meat;methods;Muscles;Sulfamethazine;Swine;
 
ABSTRACT:  An interlaboratory study of 3 methods for the determination of sulfamethazine in swine muscle and liver tissue was conducted. A gas chromatographic (CG), a combined gas chromatographic-mass spectrometric (GC/MS), and a colorimetric method were evaluated. Four fortified and 2 incurred levels of sulfamethazine ranging from 0.00 to 0.45 ppm were studied. The study revealed that the GC/MS procedure provides the most reliable data and that the GC method provides acceptable data with the incorporation of appropriate controls. The recoveries for the GC/MS method typically ranged from 90 to 100% for swine liver and muscle. The GC and GC/MS methods have been adopted official first action
 
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