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Animal model for determining the no-effect level of an antimicrobial drug on drug resistance in the lactose-fermenting enteric flora
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Rollins LD;Gaines SA;Pocurull DW;Mercer HD;
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1975
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Antimicrob Agents Chemother
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May
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JOUR
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395
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Antimicrobial agents and chemotherapy
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7
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5
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661
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665
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Animals;Anti-Bacterial Agents;Cricetinae;Diet;Digestive System;Dogs;drug effects;Drug Resistance;Drug Resistance,Microbial;Enterobacteriaceae;Escherichia coli;Fermentation;Lactose;metabolism;microbiology;Models,Biological;Oxytetracycline;pharmacology;Rats;Suspensions;
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Mature beagles were fed a ground-meal diet containing 0, 2, or 10 mug of oxytetracycline per g for 44 days. The 10-mug/g diet resulted in a shift from a predominantly drug-susceptible population of enteric lactose-fermenting organisms to a multiply antibiotic-resistant population which peaked at 78% resistant organisms. Since a shift to drug-resistant organisms did not occur in the group fed 2 mug/g, the level of oxytetracycline that results in increased incidence of antibiotic resistance lies between 2 and 10 mug/g in this dog model. Rats and hamsters fed diets containing oxytetracycline (10 mug/g or greater) or dihydrostreptomycin (10 mug/g), and provided suspensions of drug-susceptible Escherichia coli, did not develop a population of antibiotic-resistant organisms
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