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U.S. Department of Health and Human Services

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TITLE:  Characteristics of antimicrobial resistance of Escherichia coli from animals: relationship to veterinary and management uses of antimicrobial agents
 
AUTHORS:  Mercer HD;Pocurull D;Gaines S;Wilson S;Bennett JV;
 
YEAR:  1971
 
JOURNAL ABBREV:  Appl Microbiol
 
MONTH:  Oct
 
TYPE:  JOUR
 
REFMAN INDEX:  417
 
JOURNAL FULL:  Applied microbiology
 
VOLUME:  22
 
ISSUE:  4
 
START PAGE:  700
 
END PAGE:  705
 
KEYWORDS:  Ampicillin;Animal Diseases;Animal Feed;Animals;Anti-Bacterial Agents;Cattle;Conjugation,Genetic;drug effects;Drug Resistance,Microbial;Escherichia coli;Feces;isolation & purification;Microbial Sensitivity Tests;microbiology;pharmacology;Swine;Tetracycline;United States;veterinary;
 
ABSTRACT:  Five-hundred fifty-five (555) isolates of Escherichia coli were obtained from fecal specimens of a representative number of animals from five farms in the United States. Antibiotic exposure of the selected herds was determined by an epidemiological survey of these farms. The incidence of multiple resistance in the E. coli isolates was higher in herds exposed to continuous feeding of antimicrobial agents (84.8%) than in a herd not receiving antimicrobials (15.7%). The most common resistance configuration observed was the triple pattern of dihydrostreptomycin (DS), sulfonamide (SU), and tetracycline (TE). The second most frequent pattern consisted of four resistances: ampicillin (AM), DS, SU, and TE. The frequency of transfer factors was much higher in multiply resistant organisms from the herds exposed to antimicrobial medicaments. The E. coli isolates were relatively efficient in fostering and transferring heterologous resistance factors. AM resistance factors occurred more frequently in herds which were exposed to feed levels of penicillin (27.9%) than in those that were not (6.4%)
 
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